How to play:

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The Simpsons is a side-scrolling beat 'em up for up to four players, with each one playing as a member of the Simpsons family: Marge, who swings her vacuum cleaner; Homer, who punches and kicks; Bart, who wields his skateboard; and Lisa, who attacks with a jump rope. Along with the standard array of jumping and attacking, two players can team up to form a joint attack, which differs depending on which characters are used. For example, Homer can lift Bart up to use him as a melee weapon, whilst teaming him up with Marge puts them into a powerful cartwheel attack. Players can also pick up food items to restore health, as well as objects they can throw at enemies and items that temporarily power up their attacks. Players are given a small number of lives, which are lost if the player's life bar runs out. If the player runs out of life with no lives remaining (represented by a Bart-like devil appearing before them), the player has 20 seconds to add credits or the game ends. At certain points in the game, players compete against each other in button-bashing minigamesto earn additional points (computer controlled characters replace characters not being played by real people).

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The Japanese version of the game includes many differences from the North American release. These changes include throwable small scale nuclear bombs that clear all on-screen enemies. A life bar that, unlike in the North American version, can accumulate three levels by eating food beyond the first full level. The player's life is turned into bonus points after they complete a level and is restored when the next level begins. In this version there are hidden items (food and weapons) which appear when the player hits specific points of the screen. Also, in the Japanese version the score system is different: each enemy character defeated gives the player a certain number of points, while at the North American version the player only earns a single point by defeating them. This is similar to the Teenage Mutant Ninja Turtles arcade game score system.